Extended Data Fig. 3: Heterogeneity of aging rate at different ages in Jidong and Beijing cohort.

a, The standard deviation of randomly guess a number between 20–85 (n=4719, the boxes show 25%, 50% and 75% quantile and whiskers show maximum and minimum value). b, Relationship between age and the standard deviation of four AgeDiffs with bin size as 20 in Jidong cohort. Data are presented as mean +/- SD. c, Heatmap of aging-related facial features, health parameters and RNAs in Beijing (2012) cohort sorted by increasing chronological age (PCC with age, FDR < 0.05). Features were ranked by PCC from low to high (ALB: albumin, A/G: albumin/ globulin, TP: total protein, GGT: glutamyl transpeptidase, ALP: alkline phosphatase, CREA: creatinine, CHO: total cholesterol). d, e, Relationship between age and the standard deviation of four AgeDiffs with bin size as 20 (d) and 10 (e) in Beijing (2012) cohort. Data are presented as mean +/- SD.