Extended Data Fig. 5: 13C-isotopomer labeling pattern of CAC intermediates from 13C-β-HB perfusion.
From: Mitochondrial pyruvate carriers are required for myocardial stress adaptation
13C-labeled CAC intermediates analysis of Langendorff-perfused hearts perfused with [2,4-13C2]-β-HB and unlabeled glucose, palmitate and lactate. Fractional enrichment 13C-labeled isotopomers of citrate (a), glutamate (b), succinate (c), α-ketoglutarate (KG) (d), malate (e), aspartate (f) and β-hydroxybutyrate (HB) (g) were determined by LC-MS (Control, 3; cMPC1-/-, 5). Data are presented as mean ± SEM and P values were determined by two-tailed unpaired Student’s t-test.
