Extended Data Fig. 8: Effects of ketogenic diet feeding on pressure overload-induced cardiac remodeling in WT mice.
From: Mitochondrial pyruvate carriers are required for myocardial stress adaptation
a–c, 8-week-old WT C57Bl6/J mice were fed with chow and Keto Diet 1 day before TAC surgery. LV mass (a) and ejection fraction (b) were measured by echocardiography prior to surgery and 3 weeks post TAC. Heart weight normalized to tibia length (c) was determined at the time of sacrifice. (n = 5 for both groups). d–f, 12-week-old WT C57Bl6/J mice were fed with chow and Keto Diet 1 day before sham/TAC surgery. LV mass (d) and ejection fraction (e) were measured by echocardiography prior to surgery and 3 weeks post TAC. Heart weight normalized to tibia length (f) was determined at the time of sacrifice. (n = 10 for Keto Diet-TAC group and n = 5 for other groups). Data are presented as mean ± SEM and P value was determined by two-way ANOVA followed by Tukey multiple comparison test.
