Extended Data Fig. 7: A 24 hour fast improves cardiac remodeling by enhancing fat oxidation.
From: Nutritional modulation of heart failure in mitochondrial pyruvate carrier–deficient mice
a, Blood lactate of fed or fasted mice just prior to euthanasia (n = 22, 15, 16, and 14, respectively). b, Cardiac glycogen concentrations in hearts of fed and fasted mice (n = 10, 14, 15, and 14, respectively). c, Plasma TAG from fed or fasted mice (n = 22, 15, 16, and 14, respectively). d-i, Cardiac gene expression for natriuretic peptides and PPARα-target and fatty acid metabolism genes (n = 8, 9, 7, and 6, respectively). Data are presented as mean ± s.e.m. within dot plot. Each symbol on dot plot represents an individual sample. Two-way ANOVA with Tukey’s multiple comparisons test.
