Extended Data Fig. 10: NHE1 expression correlates with cyclin D1 expression and survival in MPM patients.
From: Cytosolic pH regulates proliferation and tumour growth by promoting expression of cyclin D1
(a) Representative images of histological sections stained as in Fig. 4f with high (N=45 patients) and low NHE1 (N=51 patients) expression with the corresponding cyclin D1 stainings. Scale bar represents 100 µm. (b) Kaplan Meier analysis of survival data based on high (N=49 patients) or low (N=37 patients) NHE1 expression from the TCGA-Meso cohort using log-rank test. Hazard Ratio for (with confidence interval) HR = 1.95 (1.16 - 3.30) (c) Cyclin D1 expression for patient cohorts with high and low NHE1 expression as determined in (b) Box plot (MATLAB) with median, 25th and 75th percentile, whiskers extending to most extreme points not considered outliers, and outliers (+) indicated.
