Extended Data Fig. 10: Proposed Model: PDGFRβ+ perivascular cells regulate WAT macrophage accumulation in obesity.

FIPs are a subpopulation of PDGFRβ+ perivascular cells that are capable of exerting a pro-inflammatory phenotype. In lean (chow-fed) mice, the expression of ZFP423 in FIPs serves to moderate the activation of NFκB signaling and adipose tissue inflammation, through a molecular mechanism depicted in Fig. 8g. In response to high fat diet feeding, Zfp423 expression is reduced, facilitating the activation of NFκB signaling in FIPs and the production of pro-inflammatory cytokines/chemokines required to drive the chronic macrophage accumulation and activation that occurs during prolonged high fat diet feeding.