Extended Data Fig. 1: Tracer to tracee ratio (TTR) decay curves show slow decay in torpor (red, n=9) compared to summer euthermic AGS (blue, n=5). | Nature Metabolism

Extended Data Fig. 1: Tracer to tracee ratio (TTR) decay curves show slow decay in torpor (red, n=9) compared to summer euthermic AGS (blue, n=5).

From: Nitrogen recycling buffers against ammonia toxicity from skeletal muscle breakdown in hibernating arctic ground squirrels

Extended Data Fig. 1

Tracer to tracee ratio (TTR) decay curves show slow decay in torpor (red, n=9) compared to summer euthermic AGS (blue, n=5). Decay of TTR amino acid isotopes were fitted to the equation y=a*exp(-k1*x)+b*exp(-k2*x), and area under the curve (AUC) was calculated from the integral of the two exponential curves. Rate of appearance (Ra) for each amino acid is calculated by: dose of metabolite in the pulse infusion/AUC. Whole body rate of appearance (Ra) of amino acids is a proxy for whole body production (WBP).

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