Extended Data Fig. 5: Pdgfra-TERT-KO (a-KO) females are protected from metabolism impairment.
From: Age-associated telomere attrition in adipocyte progenitors predisposes to metabolic disease
a, Echo MRI data demonstrating lower fat mass in a-KO females raised on HFD for indicated number of months. N = 5-6 mice / group. b, H&E staining demonstrates smaller BAT adipocytes and normal liver and muscle anatomy in a-KO females raised on HFD. Scale bar=50 µm. c, Quantitative RT-PCR demonstrates a lack of p16 induction, despite higher Pdgfa mRNA expression, in SAT of 4-month old a-KO females, compared to 4 month old WT females. Data normalized to 18S RNA. N = 5-6 mice / group. P: Student’s t-test (2-sided).
