Extended Data Fig. 1: Metabolic and hepatic parameters following six-week treatment of NASH C57Bl6/J mice. | Nature Metabolism

Extended Data Fig. 1: Metabolic and hepatic parameters following six-week treatment of NASH C57Bl6/J mice.

From: Resolution of NASH and hepatic fibrosis by the GLP-1R and GCGR dual-agonist cotadutide via modulating mitochondrial function and lipogenesis

Extended Data Fig. 1

Mice were treated with cotadutide, liraglutide, g1437 or liraglutide+g1437 at equimolar dosing (10 nmol/kg, SC, QD for 42 days) compared to vehicle. Animals were given ad libitum access to food for the entirety of the study except on day 14 mice were fasted for 6 h prior to ipPTT. a, Reduction in body weight throughout the 42-day dosing period shown as % change. b, Blood glucose profile during ipPTT (pyruvate given at dose of 2g/kg) and (c) area under the ipPTT curve. d, Fasting plasma insulin, (e) fasting blood glucose and (f) plasma ALT levels at the end of the study. g, Terminal liver glycogen content, (h) triglycerides and (i) cholesterol. Chow vehicle (n=10); NASH vehicle (n=11); Cotadutide (n=12); Liraglutide (n=12); g1437 (n=12); Liraglutide+g1437 (n=12). Data shown as the mean ± SEM. (a and b) Two-way ANOVA, Tukey’s multiple comparisons post-hoc test. In (a and b) colored lines and p-values indicated differences for the corresponding treatment group compared with NASH vehicle at each time point. c-i, Two-sided student’s t-test for chow controls vs. NASH vehicle to determine effect of NASH diet; One-way ANOVA, Tukey’s multiple comparisons post-hoc test, chow group excluded.

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