Extended Data Fig. 5: Cotadutide reduces hepatic fibrosis and inflammation corresponding to animals shown in Figs. 7 and 8. | Nature Metabolism

Extended Data Fig. 5: Cotadutide reduces hepatic fibrosis and inflammation corresponding to animals shown in Figs. 7 and 8.

From: Resolution of NASH and hepatic fibrosis by the GLP-1R and GCGR dual-agonist cotadutide via modulating mitochondrial function and lipogenesis

Extended Data Fig. 5

a, representative αSma stained liver sections, quantification is provided in Fig. 8d. Scale bar = 100 µm. b, representative PSR stained liver sections, quantification is provided in Fig. 8e. Scale bar = 100 µm. These experiments were performed in ob/ob mice with LFD (n=8); AMLN vehicle (n=11); Cotadutide (n=7); Liraglutide (n= 10); AMLN-to-LFD (n=10) mice/group.

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