Extended Data Fig. 1: Catecholamine signaling in white and brown adipose tissue.

Western blot analysis of WT and SAKO mice fed a HFD for 12 weeks, then treated with 1 mg/kg CL-316,243 or vehicle control for indicated time before sacrifice and tissue collection. a, Epididymal white adipose tissue. b, Inguinal white adipose tissue. Outlier detected with Grubs outlier test removed. c, Brown adipose tissue. Blots are representative of results from three independent experiments.