Extended Data Fig. 4: Expression of SEPHS2 in various types of tumor and normal tissues.
From: Selenium detoxification is required for cancer-cell survival
a, Expression profiles of SEPHS2 in 28 types of normal and tumor tissues. Normalized mRNA-Seq expression profile data from patient tumor tissues and normal tissues was obtained from GEPIA (Tang, Z. et al. (2017) GEPIA: a web server for cancer and normal gene expression profiling and interactive analyses. Nucleic Acids Res, 10.1093/nar/gkx247). Tumor subtypes having over 2-fold SEPHS2 expression in tumor than normal and q-value less than 0.01 indicated with red. q values are have been determined by ANOVA and adjusted for FDR (false discovery rate). (b and c) Box plots of SEPHS2 mRNA expression levels in patient tumors and normal breast tissue. SEPHS2 expression was compared in tumor and normal breast samples from TCGA b, and METABRIC (c) datasets. For panel b, minimum is non-tumor (-0.239), tumor (-0.6386), maximum is non-tumor (0.1874), tumor (1.0702) and median is non-tumor (0.0014), tumor (0.1402). For panel c, minimum is non-tumor (1.10097), tumor (1.26305), maximum is non-tumor (3.85158), tumor (5.67272), and median is non-tumor (1.941515), tumor (2.86621).
