Extended Data Fig. 2: Comparison of differential expressed genes in ADPKD cells, mouse and human kidney tissues. | Nature Metabolism

Extended Data Fig. 2: Comparison of differential expressed genes in ADPKD cells, mouse and human kidney tissues.

From: Super-enhancer-driven metabolic reprogramming promotes cystogenesis in autosomal dominant polycystic kidney disease

Extended Data Fig. 2

Comparison of upregulated (a) and downregulated (c) genes in cells, mouse and human kidney tissues. Gene ontology enrichment analysis of the overlap upregulated genes (b) and downregulated genes (d). Numbers beside bars indicate numbers of differently expressed genes in that GO category. P values obtained by hypergeometric test. e, Scatter plot showing expression changes of SE-driven genes in cells and mouse kidney tissues. x-axis: log2 (fold change) from PN versus PH cells; y-axis: log2 (fold change) from ADPKD mouse kidney tissues versus normal kidney tissues. f, Heatmap demonstrating expression values of 29 candidate genes in cells and mouse kidney tissues. Rows show Z scores calculated for each group.

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