Extended Data Fig. 3: Effects of THZ1 treatment on cell proliferation, apoptosis and body weight in ADPKD mouse model.
a, Immunohistochemistry analysis of PCNA expression in P29 Pkd1−/− mice injected with THZ1 or DMSO, n = 3 biologically independent mice per group; Data are represented as means ± s.e.m. Unpaired two-sided Student’s t-test was used for statistical analysis, **P = 0.0051. b, Immunofluorescence analysis of TUNEL level from P29 Pkd1−/− mice injected with THZ1 or DMSO, n = 3 biologically independent mice per group; Data are represented as means ± s.e.m. Unpaired two-sided Student’s t-test was used for statistical analysis, *P = 0.0161. c, Body weight of mice from late-onset ADPKD mouse model. Scale bars, 10 µm (a) and 50 µm (b).
