Extended Data Fig. 9: Ribbon plots for the association between DNAme at candidate loci (HbA1c-associated CpGs) and expression of genes located within 500 bp (FDR < 0.05) that were observed only in CD4+ cells (not in monocytes).
From: DNA methylation mediates development of HbA1c-associated complications in type 1 diabetes
The associations of DNAme at HbA1c-associated CpGs with the expression of gene(s) in CD4+ T cells were analyzed on each pair of HbA1c-associated CpGs and corresponding nearby genes within 500 kb. Multiple linear regression models using two-sided tests based on t-statistic were applied to published datasets containing both DNAme and gene expression profiles from same CD4+ T cell samples (n=214) to identify HbA1c-associated CpGs whose DNAme is associated with the expression of nearby gene(s) (expression-associated genes) with FDR < 0.05. The order of the CpGs is based on significance level of the CpG with its most significantly associated gene (expression data). The height of the ribbon represents the significance level in –log10(P). Blue indicates negative association while red indicates positive association. Grey represents the associations with nominal P < 0.05 but FDR >0.05.
