Extended Data Fig. 2: Sensitivity analyses of additional clinical variables on the percentage of association coefficients changes between mean-DCCT HbA1c and DNAme at the HbA1c-associated CpGs.
From: DNA methylation mediates development of HbA1c-associated complications in type 1 diabetes
For each HbA1c-associated CpG, one additional clinical variable (indicated on top of each plot) was added as covariate in the multiple linear regression model with two-sided tests based on t-statistic used for identification of HbA1c-associated CpGs using all the samples (n=499). For each clinical variable, the percentage change of the resulting association coefficients versus the coefficients estimated using the original model without the specific variable was calculated. For each additional variable, the distribution of the calculated changes was plotted using density plots. Abbreviations: COEF-coefficient; SBP- systolic blood pressure; DBP-diastolic blood pressure; BMI-body mass index; CHL-cholesterol; TRG-triglyceride; LDL-low density lipoprotein; HDL-high density lipoprotein; PDR- proliferative diabetic retinopathy; SNPDR-severe nonproliferative diabetic retinopathy; CSME- clinically significant macular edema; AER30-AER > 30 mg/24 h; CARV-cardiovascular disease.
