Extended Data Fig. 2: Extended Data Figure 2: Baseline exercise capacity.
From: Hyperglycaemia is associated with impaired muscle signalling and aerobic adaptation to exercise
Three separate cohorts of CD-1 mice were fed with Western Diet (WD), injected with streptozotocin (STZ) or maintained on a control diet (CON). After 8 weeks of treatment, all mice underwent aerobic exercise capacity testing in a and were found to have similar exercise capacities prior to being allocated to treatment groups for the training intervention (CON n=34, WD n=32, STZ n=42). Mice from each treatment group (CON, WD, STZ) were then allocated to remain sedentary or undergo voluntary wheel running (exercise-training) for a further 8 weeks. Baseline (pretraining) exercise capacity, shown in b, was similar among all six treatment groups (CON SED n=17, WD SED n=16, STZ SED n=22; CON EXT n=17, WD EXT n=16, STZ EXT n=20). Main effects were determined by one-way ANOVA relative to CON group in a and by two-way ANOVA in b. Data is represented as a point for the result of each individual animal, or mean ± SEM.
