Extended Data Fig. 4: Fructose-induced alterations in the liver transcriptome.
From: Fructose stimulated de novo lipogenesis is promoted by inflammation
a, KEGG pathway map of innate immune signaling with HFrD-induced genes indicated in red. b, Heatmap depicting the entire transcriptome of non-tumor liver tissue from DEN-treated BL6 male mice kept on CSD (n = 3) or HFrD (n = 2) for 5 months and analyzed immediately thereafter. c, Heatmap depicting the entire transcriptome of tumor-bearing liver tissue from DEN-treated BL6 male mice kept on CSD (n = 2) or HFrD (n = 3) until 9 months old. d, Heatmap depicting expression of HCC-related genes in non- tumor and tumor liver tissues from mice described in (b). The color code represents relative mRNA abundance where red shows overexpression and blue shows under expression. e, Most significant Gene Ontology enrichment terms for Biological Pathways for the genes shown in heatmap (b) comparing DEN-treated BL6 mice fed a CSD or HFrD at 6 months of age. The bigger the dot, the more genes fall in the respective category. The color code represents the adjusted P- value (all are significant and below a cut-off level of 0.01) determined using Benjamini-Hochberg FDR adjustment.
