Extended Data Fig. 8: Associations between age and gut microbiome measures across health stratifications in the MrOS cohort.

a–e, Plots demonstrating the strength of Spearman correlation between age and gut microbiome measures at different taxonomic resolutions. a, The blue/red panel corresponds to the calculated Weighted UniFrac (ß-diversity) uniqueness score at the genus level, while (b) the grey/green and (c) grey/yellow panels correspond to Shannon diversity and Observed species (α-diversity measures) at the ASV level, respectively. Significant correlations (two-sided) are indicated with asterisks. Exact correlation coefficients and corresponding p-values for (a) are provided in Extended Data Fig. 7. d-e, The same plots as in (b-c), with α-diversity calculated at the genus level. f, Comparison of ASV level and genus-level analysis in healthy ageing in the MrOS cohort. Barplots represent correlation coefficients comparing age and uniqueness at the ASV level across composite healthy MrOS individuals, and the remainder of the cohort in both the discovery and validation groups. g, ß-coefficients for age from OLS regression models predicting genus-level Bray-Curtis uniqueness in healthy composite individuals and remainder of the cohort, adjusted individually for the most commonly reported supplements and medications in the MrOS cohort.