Extended Data Fig. 3: Associations between age and gut microbiome uniqueness across cohorts using different distance metrics.

a, Age ß-coefficients and corresponding P-values from OLS models predicting Bray-Curtis uniqueness at the ASV- and genus-level in the American Gut Project (AGP) and two vendors in the Arivale cohort. In the AGP dataset, the analysis was performed on all samples, and then repeated on the subset of samples who had available sex and BMI data for covariate adjustment. P-values reported are derived from OLS linear regression models and result from a two-sided hypothesis. b, Spearman correlations of different ß-diversity metrics with age on both the ASV- and genus-level independently in each vendor used for gut microbiome processing in the Arivale cohort.