Extended Data Fig. 4: Expression of appetite-supressing receptors in mice and non-human primates.
From: A genetic map of the mouse dorsal vagal complex and its role in obesity
a, Representative image showing db-ISH of GFRALASR (blue) and GLP1R (red) in non-human primates (n=2). Scale bar, 250 μm. b, Representative image showing db-ISH of CALCR (blue) and GLP1R (red) in non-human primates (n=2). Scale bar, 100 μm. c, Representative image showing db-ISH of CASR (blue) and GLP1R (red) in non-human primates (n=2). Scale bar, 250 μm. d, Representative image showing db-ISH of Grpr (blue) and Calcr (red) in mice (n=4). Scale bar, 100 μm. e, Representative image showing db-ISH of Casr (blue) and Bdnf (red) in mice (n=4). Scale bar, 100 μm. f, Representative image showing db-ISH of Grpr (blue) and Bdnf (red) in mice (n=4). Scale bar, 100 μm. g, Representative image showing db-ISH of Casr (blue) and Mc4r (red) in mice (n=4). Scale bar, 100 μm. h, Representative image showing db-ISH of Grpr (blue) and Mc4r (red) in mice (n=4). Scale bar, 100 μm. i-l, Representative images showing TH (purple) or DDC immunoreactivity (purple) and GFP immunoreactivity (green) in Glp1r-Cre;GFP or Calcr-Cre;GFP mice (n=3). Scale bar, 150 μm.
