Extended Data Fig. 2: Colchicine at a safe dose selectively targets hepatocytes.
From: Colchicine acts selectively in the liver to induce hepatokines that inhibit myeloid cell activation
Additional images related to Fig. 1g. Microtubules in the livers of mice treated with a, vehicle or b, 0.4 mg/kg colchicine. Livers were collected 6 hours after treatment. Colchicine selectively depolymerized microtubules in hepatocytes, identified by HNF4+. The boxed areas are magnified and shown at the bottom. Liver cells from 4 livers with vehicle or colchicine treatment respectively. Scale bars, 10 μm.
