Extended Data Fig. 5: Metabolic profile in thermoneutrality condition.
From: TFEB–GDF15 axis protects against obesity and insulin resistance as a lysosomal stress response
a-e, Body weight (a), body weight gain (b), adipose tissue weight (c), H&E staining of adipose tissues (d) and serum GDF15 (e) in HFD-fed TFEBMac-Tg and control mice housed at normal ambient (22 °C) or thermoneutral temperature (30 °C) (n=6-12). Scale bars, 200 μm. All data are shown as means ± SEM. *P < 0.05, **P < 0.01 and ***P < 0.001 by two-way ANOVA with Bonferroni’s test (a) or one-way ANOVA with Tukey’s test (b,c,e). (n.s., not significant).
