Extended Data Fig. 7: Metabolic profile of chow- or HFD-fed GDF15-Tg mice.
From: TFEB–GDF15 axis protects against obesity and insulin resistance as a lysosomal stress response
a-c, Body weight (a), GTT (b) and ITT (insulin 1.5 U/kg) (c) in GDF15-Tg and control mice fed chow diet or HFD for 12 weeks (n=3-4). d-h, Food intake (d), tissue weight (e), representative H&E staining of eWAT, iWAT, BAT and the liver (f), serum ALT/AST (g) and serum CHO/FFA/TG levels (h) in GDF15-Tg and control mice fed chow diet or HFD for 12 weeks (n=3-4). Scale bars, 200 μm. i, Representative TH immunohistochemistry of BAT and iWAT in GDF15-Tg and control mice fed HFD for 12 weeks. Arrows indicate cells with positive TH staining. Scale bars, 50 μm for BAT and 200 μm for iWAT. All data are shown as means ± SEM. *P < 0.05, **P < 0.01, and ***P < 0.001 by two-way ANOVA with Bonferroni’s test (a,b,c) or one-way ANOVA with Tukey’s test (e,g,h). (In a-c, *P < 0.05, **P < 0.01 and ***P < 0.001 between GDF15-Tg and control mice fed chow diet. #P < 0.05, ##P < 0.01, and ###P < 0.001 between GDF15-Tg and control mice fed HFD). (n.s., not significant).
