Extended Data Fig. 6: BRD4 ChIP-seq in REDS15 cells upon purine metabolism impairment. | Nature Metabolism

Extended Data Fig. 6: BRD4 ChIP-seq in REDS15 cells upon purine metabolism impairment.

From: Cell-surface SLC nucleoside transporters and purine levels modulate BRD4-dependent chromatin states

Extended Data Fig. 6

a, Principal component analysis on BRD4 ChIP-seq raw counts in cells with indicated treatments. Upper panel, with 3 replicates of individual treatment. Lower panel, with replicate number 3 in 6-MP treated group (6-MP_BRD4_IP_rep3) excluded. b, Heatmaps representing BRD4 binding enrichment for all ChIP-seq consensus peak regions (N = 24,140) in individual replicates. c, Aggregate coverage plots showing mean enrichment for the different ChIP-seq consensus peak regions in cells with 10 μM 6-MP or 1 μM (+)-JQ1 treatment or bearing triple SLC knockout (SLC TKO), with ±10 kb centred on the regions. d, Genome browser visualization of BRD4 binding at its representative target genes MYC and BCL-2 in cells with indicated treatments.

Back to article page