Extended Data Fig. 3: Purine supplementation attenuates BRD4 inhibition phenotype in exogenous nucleosides limited condition.
From: Cell-surface SLC nucleoside transporters and purine levels modulate BRD4-dependent chromatin states
a, Relative RFP intensity in REDS1 and REDS15 clones cultured in medium supplemented with 10% dialyzed serum (dFBS) over time. The log2 fold change of the RFP intensity was normalized with cells cultured in medium supplemented with 10% FBS. Mean ± s.d., n = 3 biologically independent samples. The p-value was calculated by unpaired t-tests. b, Relative RFP intensity in REDS15 cells after growing in medium supplemented with 10% dFBS for 10 days and further exogenously added with purine (adenosine and guanosine) or pyrimidine nucleosides (cytidine and thymidine) for 72 h. Mean ± s.d., n = 3 biologically independent samples.
