Extended Data Fig. 6: RNA-seq analysis of MycΔIE, ERT2 mice fed a HFD for 2 weeks.
From: Intestinal MYC modulates obesity-related metabolic dysfunction
a-j, Mycfl/fl and MycΔIE, ERT2 mice were injected with tamoxifen and fed a HFD for 2 weeks. a, Body weight curve. b, Liver weight. c, Serum ALT. d, Serum AST. e, Serum triglyceride. f, Serum total cholesterol. g, Hepatic triglyceride. h, Hepatic total cholesterol. a-h, n = 7. i, Glucose tolerance test. j, Insulin tolerance test. i,j, n = 9 for Mycfl/fl mice and n = 10 for MycΔIE, ERT2 mice. *P = 0.0113 (GTT, 30 min), 0.0497 (GTT, 60 min), 0.0103 (ITT, 60 min), 0.0224 (ITT, 90 min). All data are presented as mean ± S.E.M. of biologically independent samples, analyzed using a two-tailed Student’s t-test (a-j). The PCA plot (k), volcano plot (l) and pathway enrichment (m) of the RNA-seq data from the intestines of Mycfl/fl and MycΔIE, ERT2 mice injected with tamoxifen and fed a HFD for 2 weeks.
