Extended Data Fig. 4: Protein changes in EVs from four temporal stages of COVID-19.
a,b, Levels of complement C1q subcomponent subunit A (a) and complement C1q subcomponent subunit C (b) in EVs across four temporal stages of COVID-19 quantitated by proteomics (n = 3 independently pooled patient samples) were analysed for each clinical stage. P-value from two-sided Games-Howell’s test for pair-wise comparisons were indicated. c-d, Immunoblot analyses of premature SP-C (c) and caspase 3 proenzyme (d) (n = 3 for S1, S3, S4; n = 4 for S2; n = number of patients). Data were presented as mean + SEM. P-value from two-sided Dunn’s test for pair-wise comparisons were indicated. P < 0.05 was considered statistically significant. NS: non-significant.
