Extended Data Fig. 2: Transcriptomics and proteomics analyses of mock- and ZIKV-infected brains.
From: Aberrant NAD+ metabolism underlies Zika virus–induced microcephaly
a, Principal component analysis for the detected proteins in mock- and ZIKV-infected brains. b-c, Top 10 most significant GO terms enriched by significantly upregulated (red) and downregulated (blue) proteins (FDR < 0.05 and fold change > 2) in ZIKV-infected brains, respectively. d-e, Heatmap of significantly altered proteins (FDR < 0.05 and fold change > 2) related to cytokine response (d) and axon development (e). f, Inflammatory cytokine alterations induced by ZIKV infection at mRNA level (data from our transcriptomics datasets, n = 3 mice per group). Data are shown as mean ± s.e.m. Two-tailed unpaired t-test was used for statistical analysis. Exact P values are indicated. g, Cell type enrichment scores (ES) calculated by GSVA using proteomics data of ZIKV-infected brains and mock-infected controls. Enrichment scores demonstrating the relative abundance of distinct cell types were shown in orange (increased) and green (decreased).
