Extended Data Fig. 5: Metabolomic profile of skeletal muscle from AL, Diluted AL and CR mice. | Nature Metabolism

Extended Data Fig. 5: Metabolomic profile of skeletal muscle from AL, Diluted AL and CR mice.

From: Fasting drives the metabolic, molecular and geroprotective effects of a calorie-restricted diet in mice

Extended Data Fig. 5

Targeted metabolomics were performed on skeletal muscle from male C57BL/6J mice fed AL, Diluted AL, and CR diets (n = 10 biologically independent mice per diet). a) Heatmap of 28 targeted metabolites, represented as log2-fold change vs. AL-fed mice. b) sPLS-DA of skeletal muscle metabolites. c) Relative abundance of amino acid metabolites. d) Relative abundance of TCA cycle metabolites. (a–d) * symbol represents a significant difference versus AL mice (p ≤ 0.05); # symbol represents a significant difference versus Diluted AL mice (p ≤ 0.05) based on Tukey’s test post one-way ANOVA. Overlaid box plots show center as median and 25th-75th percentiles; whiskers represent minima and maxima.

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