Extended Data Fig. 9: Additional data for C57BL/6J male mice fed CR or TR.al diets.
a) Food consumption (n = 12 biologically independent mice per diet). b-e) Body composition (body weight, lean mass, fat mass and adiposity) of C57BL/6J male mice fed the indicated diets for 4 months (n = 12 biologically independent mice per diet; statistics on supplementary table 7). F-G) Glucose (n = 12 biologically independent mice per diet) (f) and insulin (AL, n = 12; TR.al, n = 12; CR, n = 11 biologically independent mice) (g) tolerance tests were performed after 13-14 weeks, respectively on the indicated diets. (h-j) Fasting blood glucose (h), fasting and glucose-stimulated insulin secretion (15 minutes) (i), and calculated HOMA2-IR (j) (AL, n = 12; TR.al, n = 11; CR, n = 12 biologically independent mice). * symbol represents a significant difference versus AL (TR.al, p ≤ 0.0018; CR, p ≤ 0.0477); # symbol represents a significant difference versus TR.al (MF.cr, p ≤ 0.0187; CR, p = 0.0478) based on Tukey’s test post one-way ANOVA. All data are represented as mean ± SEM.
