Extended Data Fig. 1: Additional measures of glucose homeostasis in male C57BL/6J mice.
(a) Food Consumption (b) Glucose (AL, n = 12; Diluted AL, n = 10; MF.cr, n = 11; CR, n = 12 biologically independent mice) (c) and insulin (AL, n = 12; Diluted AL, n = 11; MF.cr, n = 10; CR, n = 8 biologically independent mice) tolerance tests after 13 or 14 weeks on the indicated diets. * symbol represents a significant difference versus AL-fed mice (p = 0.0009); # symbol represents a significant difference versus Diluted AL-fed mice (p = 0.0021); * symbol represents a significant difference versus MF.cr-fed mice (p = 0.0013) based on Tukey’s test post one-way ANOVA. (D-F) Fasting blood glucose (d), fasting and glucose-stimulated insulin secretion (15 minutes) (e), and calculated HOMA-IR (F). (d-f) AL, n = 9; Diluted AL, n = 8; MF.cr, n = 9; CR, n = 9 biologically independent mice; * symbol represents a significant difference versus AL-fed mice (Diluted AL, p = 0.0256; CR, p = 0.0127); insulin levels in fasted and glucose-stimulated states were analyzed separately. All data are represented as mean ± SEM.
