Extended Data Fig. 8: Intermittent administration of PCC1 alleviates physical dysfunction of aged mice.
From: The flavonoid procyanidin C1 has senotherapeutic activity and increases lifespan in mice
(a) Representative images of SA-β-Gal staining of liver tissues from young (6 months of age) and aged males treated with vehicle or PCC1. Scale bar, 200 μm. (b) Comparative statistics of SA-β-Gal staining positivity of samples assayed in (a). (c) Representative images of SA-β-Gal staining of lung tissues from young and aged mice treated with vehicle or PCC1. Scale bar, 200 μm. (d) Comparative statistics of SA-β-Gal staining positivity of samples examined in (c). (e) Representative images of SA-β-Gal staining of prostate tissues from young and aged mice treated with vehicle or PCC1. Scale bar, 200 μm. (f) Comparative statistics of SA-β-Gal staining positivity of samples examined in (e). (g) Quantification of body weight of animals as described in (a). (h) Measurement of food intake of animals as described in (a). Data in g and h are representative of 3 biological replicates (n = 10 animals per group). Datasets are displayed as box-and-whisker plots, where a box extends from the 25th to 75th percentile with the median shown as a line in the middle, with whiskers indicating smallest and largest values. Data in bar graphs (b, d and f) are shown as mean ± SD (n = 5 animals per group) and representative of 3 independent experiments. For b, d, f, g and h, P values were calculated by two-sided t-test. ^, P > 0.05. *, P < 0.05. **, P < 0.01. ***, P < 0.001.
