Extended Data Fig. 3: Opa1 promotes browning of white adipocytes.

(a) Expression fold change (SAT vs. VAT) of the indicated BAT specific and mitochondrial genes in Wt mice (n = 4-5). Dots indicate individual mice, center lines mean, whiskers SEM. *, p = 0.019 for Opa1, Ucp1, Pgc1α; p = 0.03 for Cox8b; p = 0.05 for CideA. (b) Electron microscopy (EM) images from SAT and VAT of Wt and Opa1^tg mice treated for 5 days with 10 mg/kg CL316,243 (CL), administered i.p. every day (n = 6 independent experiments). Scale bar: 5 µm.

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