Extended Data Fig. 5: Opa1 controls fumarate levels in vivo. | Nature Metabolism

Extended Data Fig. 5: Opa1 controls fumarate levels in vivo.

From: The mitochondrial protein Opa1 promotes adipocyte browning that is dependent on urea cycle metabolites

Extended Data Fig. 5

(a) Average+SEM of metabolite levels in mature adipocytes from SAT of Wt and Opa1tg mice (n = 3). Metabolites with a significantly different mean concentration in Opa1tg vs Wt adipocytes are highlighted in the inset. * p = 0.049 in a Kruskal-Wallis ANOVA test. (b) Fumarate levels in 40 mg of SAT isolated from Wt (n = 4) and Opa1tg (n = 6) mice. Box represents mean ± SEM, whiskers the 10th-90th percentile. **p = 0.014 in a two-tailed Mann-Whitney U test. (c) Metabolites in (a) and (b) were analyzed using the Pathway Analysis module of MetaboAnalyst tool. Red dots show the top significantly relevant pathways.

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