Extended Data Fig. 10: KDM3a and CPS1 are reduced in WAT of obese individuals.
(a,b) Box-dot plots of quantitative PCR analysis of KDM3A (a) and CPS1 (b) transcripts from abdominal wall fat pad biopsies of 5 lean subjects, 15-17 obese normoglycemic subjects (Obese), and 17-19 obese diabetic patients (Obese-T2DM). Data are normalized for the expression of S18. *, p = 0.01 (Obese vs. Lean) and p = 0.03 (Obese-T2DM vs. Lean) for KDM3A and p = 0.02 for CPS1 in a one way ANAOVA test. (c,d) Pearson correlation analysis of OPA1 with KDM3A (c) and CPS1 expression (d) in lean and individuals with obesity as in (a,b).
