Fig. 4: LbNOX redox state in liver drives energy conservation during nocturnal CR feeding.
From: NADH inhibition of SIRT1 links energy state to transcription during time-restricted feeding
TRF-CR generates rhythmic bouts of daytime torpor through increased levels of NADH in liver, inhibition of SIRT1 and downregulation of oxidative gene networks controlling acyl-carnitines and core body temperature. Reducing levels of NADH in the morning through the transduction of LbNOX in TRF-CR mice increases lipid oxidation through the activation of SIRT1, resulting in elevated daytime body temperature rhythms. These findings identify NAD(H) redox state as a link between TRF-CR and whole-body metabolismļ»æ.
