Extended Data Fig. 7: IR^∆Tan-mice exhibit an increased propensity for repetitive and compulsive behaviours.

a-e. Open field test (5 min) of IR^GFP-Tan and IR^ΔTan mice, n = 13/ IR^GFP-Tan, n = 14/ IR^ΔTan. a. Time spent in outer-zone during 5 min open field test. b. Distance travelled in inner, outer and in total during 5 min long open field test. p(outer zone) = 0.0069, p(total) = 0.006. c. Mean speed during open field test, p = 0.0087. d. Rearing counts during 5 min long open field test. e. Rearing time in inner, outer and in total during 5 min open field test p(outer zone) = 0.0366, p(total) = 0.0665. f-i. Layout of marble burying test (f). Burying behaviour of 18 marbles was determined over 30 min in IR^GFP-Tan and IR^ΔTan mice, n = 16/mice group. g. Burying behaviour of 18 marbles of IR^GFP-Tan and IR^ΔTan mice during 30 min long marble burying test, Two-way ANOVA p = 0.037, p(30 min) = 0.0519, (two way-ANOVA, Šídák post-hoc test). h. Count of total marbles buried after 30 min measurement, p = 0.0439. i. Latency to bury marbles, p = 0.0294. b, c, e, h, i. unpaired, two-tailed Student’s t-test. a – e, h – i. Data are represented as the mean ± SEM.

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