Extended Data Fig. 3: Increase in circulating GP73 elevates fasting blood glucose.
From: GP73 is a glucogenic hormone contributing to SARS-CoV-2-induced hyperglycemia
a-d, Plasma glucagon (a), epinephrine (b), norepinephrine (c) and serum corticosterone (d) levels 15 min after rmGP73 or GFP injection (n = 3 or 4). ns, no significant for rmGP73 versus GFP by two-tailed Student’s t-tests (a-d). e, Glycogen levels in mice at 30 and 60 min after rmGP73 or GFP injection (n = 3 in each group). ns, no statistical significance for rmGP73 versus GFP (0 min, 30 min and 60 min) by two-tailed Student’s t-tests (a-d). f, Schematic representation of the metabolic process responsible for GP73-induced hyperglycemia. Animal studies were performed independently at least three times with comparable results. The data were presented as the means ± SEMs. ns, no statistical significance.
