Extended Data Fig. 6: GP73 stimulates gluconeogenesis.
From: GP73 is a glucogenic hormone contributing to SARS-CoV-2-induced hyperglycemia
a, Timeline of the procedure for performing the insulin clamp. The figure was created and exported with BioRender.com under a paid subscription. b, The equations used to calculate and evaluate insulin sensitivity. c-f, GP73 levels (c), blood glucose levels (d), GIR (e), and APE (f) in GP73 KO mice infused with GFP or recombinant GP73 during the clamp study. P < 0.0001 for rmGP73 versus GFP (basal and clamp) (c), P = 0.0029 for rmGP73 versus GFP (10 min), P = 0.0028 for rmGP73 versus GFP (20 min), P = 0.0068 for rmGP73 versus GFP (30 min), P = 0.0150 for rmGP73 versus GFP (40 min), P = 0.0489 for rmGP73 versus GFP (50 min), P = 0.0059 for rmGP73 versus GFP (60 min), P = 0.0258 for rmGP73 versus GFP (70 min), P = 0.0315 for rmGP73 versus GFP (80 min), P = 0.0137 for rmGP73 versus GFP (90 min), P = 0.0264 for rmGP73 versus GFP (100 min), P = 0.0049 for rmGP73 versus GFP (110 min), P = 0.0049 for rmGP73 versus GFP (120 min) by two-tailed Student’s t-tests (e), P = 0.0115 for rmGP73 versus GFP (basal) and P = 0.0048 for rmGP73 versus GFP (clamp) (f) by two-tailed Student’s t-tests. Hyperinsulinemic-euglycemic clamp studies were performed independently at least three times with comparable results. The data were the means ± SEMs. *P < 0.05; **P < 0.01; ***P < 0.001.
