Extended Data Fig. 9: G6PD and PGD blockade affects oxPPP metabolites. | Nature Metabolism

Extended Data Fig. 9: G6PD and PGD blockade affects oxPPP metabolites.

From: Oxidative pentose phosphate pathway controls vascular mural cell coverage by regulating extracellular matrix composition

Extended Data Fig. 9

a, Gluconate-6P, ribulose/ribose/xylulose-5P, GAP/DHAP, glucose/fructose-6P, and sedoheptulose-7P relative abundance in control and G6PDKD cells. Control (n=5) and KD (n=4) from two independent experiments. Data are shown as mean ± SD. Statistics were assessed using Student’s t-test followed by false discovery rate (FDR) correction was applied. b, Relative NADP/NADPH ratio, ATP energy charge, and GSH/GSSG ratio in control and G6PDKD cells. Data are shown as mean ± SEM, parametric-unpaired Student’s t-test was applied. c, Total levels of nucleotides, ribonucleotides, and deoxyribonucleotides of control, G6PDKD and PGDKD EC. n=10 from two independent experiments. Data are shown as mean ± SEM. For statistical analysis the one-way ANOVA followed by Tukey’s test multiple comparison was applied.

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