Fig. 2: PSD3 mRNA isoform expression in human liver and total PSD3 mRNA expression stratified by rs71519934 genotype.
From: PSD3 downregulation confers protection against fatty liver disease
a, Expression level of the different PSD3 mRNA isoforms in human liver tissue. To assess which isoform is the most abundant, the transcriptome from liver biopsies of a subset of 77 individuals from the Milan subgroup of the LBC was examined. Isoform 001 (identified as ENST00000327040 by Ensembl or as NP_056125 (isoform-a) by NCBI, 1,047 amino acids) had the highest expression, followed by isoform 008 (identified as ENST00000521841 by Ensembl, non-coding). Data are presented as mean and s.d. b, Total PSD3 mRNA expression stratified by rs71519934 genotype. There were no differences in PSD3 mRNA expression levels when stratified by genotype. c, Total NAT2 mRNA expression levels did not differ among PSD3 rs71519934 genotypes. b,c, Data are presented as mean and s.d. The two-sided P value was calculated by unadjusted linear regression. Values were log-transformed before entering the model. FPKM, fragments per kilobase of exon model per million reads mapped; 186L, homozygotes for the L allele (n = 42); L186T, heterozygotes (n = 29); 186T, homozygotes for the T allele (n = 6).
