Extended Data Fig. 10: BCKA reverses the lean phenotype conferred by TEL.
From: BCAA–BCKA axis regulates WAT browning through acetylation of PRDM16
(a)Body weight gain from mice as indicated groups. n=5 mice. (b) GTT and ITT data from mice as indicated groups. n=5 mice. (c) HE staining of liver histology from mice as indicated groups. Representative result from 4 mice. (d) Ucp1 and Cidea expression for iWAT from mice as indicated groups. Ucp1 and Cidea protein levels as indicated were quantified and normalized against Tubulin. n=3 mice. Bars and error bars represent mean values and SDs, with biologically individual data points shown. n, cohort size. P values are derived from unpaired, two-tailed t-test (a), or repeated-measures 2-way ANOVA followed by Sidak’s multiple-comparison test (b).
