Extended Data Fig. 9: GS is overexpressed in human NSCLC and contributes to resistance to microtubule drugs in vivo.
From: Glutamine synthetase licenses APC/C-mediated mitotic progression to drive cell growth
a, Quantification of the body weight of the H460 tumor-bearing nude mice in both solvent control and paclitaxel treatment cohorts. (n=10 for each group of the H460-innoculated mice). b, Quantification of weight of tumors dissected from nude mice injected with the indicated cells and treated with solvent control (PBS) or paclitaxel (5 mg/kg) every other day in vivo for 16 days. (n=10 for each group of the H460-innoculated mice). c, Representative images of tumors of b. d, Quantification of GS expression in a tissue array containing 16 normal lung tissues and 86 lung cancer samples (right). Data were presented as mean±s.e.m. Unpaired, two-tailed t-test was applied for b. χ2 test was applied for d. *: p<0.05, **: p<0.01.
