Extended Data Fig. 9: Working model for an FGF21-independent role of KLB in regulating insulin secretion.
From: β-Klotho promotes glycolysis and glucose-stimulated insulin secretion via GP130
KLB interacts with GP130 and prevents ubiquitin-dependent lysosomal degradation of GP130, thereby facilitating IL6-induced STAT3–HIF1α signaling to maintain normal glycolysis and GSIS in pancreatic β-cells.
