Fig. 5: Deletion of p53 in skin adipocytes abrogates UVB-induced appetite enhancement.
From: Food-seeking behavior is triggered by skin ultraviolet exposure in males
a,b, Relative weekly body weight of male (a) and female (b) mice after 4 weeks of daily UVB (50 mJ/cm2) or control irradiation (Males: n = 10 biologically independent p53flx/flxFabp4Cre+ mice per condition and n = 7 biologically independent p53flx/flxFabp4Cre- mice per condition; Females: n = 9 biologically independent p53flx/flxFabp4Cre+ mice per condition and n = 11 biologically independent p53flx/flxFabp4Cre- mice per condition). c, Experimental design. d,e, Responses of control and p53-cKO (d) male and (e) female mice in the open-field test after 5 weeks of exposure to UVB (50 mJ/cm2) or mock-UVB (control) irradiation (n = 10 biologically independent male mice per condition and n = 11 biologically independent female mice per condition). Right panel: Representative heat map images from the video of the test session. f, Plasma protein levels of ghrelin in UVB (50 mJ/cm2) or mock-UVB (control)-irradiated control and p53-cKO male (left panel) and female (right panel) mice after 5 weeks of treatment (n = 9 biologically independent mice per condition). In all relevant panels: Data are presented as mean ± SEM; Two-tailed unpaired t-test p-values are shown, or statistical details for sex or UVB or p53-cKO factors in the ANOVAs (F-values, degrees of freedom, p-value) with interaction appears in Supplementary Table 10, or two-way ANOVA analysis with multiple correction test appears in Supplementary Table 11.
