Extended Data Fig. 9: Gene expression correlations between lipid metabolism genes and hypoxia signature genes.
From: Cancer cells depend on environmental lipids for proliferation when electron acceptors are limited
a, Pearson correlation coefficients and corresponding p-values, for each of 34 different tumor types, between expression of hypoxia signature genes and expression of fatty acid synthesis genes (third column), lipid uptake genes (fourth column), and beta-oxidation genes (fifth column). Insignificant correlations, based on the 1% FDR cutoff, are marked in red. Depicted p-values on Pearson correlation coefficients are calculated using two-sided Student’s t-test, and significance threshold is adjusted for multiple comparisons at 1% FDR using the Benjamini-Hochberg method. b, Scatter plots showing, for each considered tumor type, the correlation between the tumor hypoxia score and expression of genes participating in fatty acid synthesis, with dots representing individual TCGA samples. c, Scatter plots showing, for each considered tumor type, the correlation between the tumor hypoxia score and expression of genes participating in lipid uptake, with dots representing individual TCGA samples.
