Extended Data Fig. 8: Knockdown of D2R in the LHA/ZI reverses the effects of prolonged breastfeeding in liver.
From: Prolonged breastfeeding protects from obesity by hypothalamic action of hepatic FGF21
a–c, Effect of injecting adenoviral particles encoding for GFP- or D2R-KD in the LHA/ZI of rats fed HFD with prolonged breastfeeding period on cumulative food intake (a); oil red area in Liver (b); plasma triglycerides (c). Values are represented as means ± SEM, n per group indicated in each figure. Exact P values are shown. Statistical differences according to a One-way analysis of variance ANOVA (normal data and homogeneity of variances) followed by Tukey’s post hoc multiple comparison test (a, b) or to a two-sided Mann-Whitney U-test (non-normal data and non-homogeneous variance) (c).
