Fig. 5: GLP-1RA/tesaglitazar in obese GLP-1R knockout mice.
From: GLP-1-mediated delivery of tesaglitazar improves obesity and glucose metabolism in male mice
a–n, Body weight (a,h), change in fat and lean tissue mass (b,c,i,j), cumulative food intake (d,k), blood glucose (e,l) and i.p. GTT (f,m) in 36-week-old male DIO wildtype (WT) (a–g) or GLP-1R knockout (KO) mice (h–n) treated for 6 days with either vehicle or 50 nmol kg−1 per day of GLP-1RA/tesaglitazar. Sample sizes for treatment with Vhcl or GLP-1RA/tesaglitazar are n = 8/8 (a–c,e,f), n = 8/7 (g) and n = 7/7 (h–j,l–n). Cumulative food intake was assessed per cage in n = 4/3 cages containing n = 8/8 mice (d) and n = 4/5 cages containing n = 7/7 mice (k). Data in a, d, f, h, k and m have been analysed by two-way ANOVA with Bonferroni post hoc comparison for individual time points. Data in b, c, e, g, i, j, l and n have been analysed by one-way ANOVA using Bonferroni’s multiple comparison test. Data represent means ± s.e.m.; asterisks indicate *P < 0.05, **P < 0.01, ***P < 0.001. Exact P values for treatment effects are: a,b,d–f, P < 0.0001; c, P = 0.0003; g, P = 0.0078. For exact P values at individual time points (a,d,f,h,k,m), see the data source file.
