Fig. 1: Elevated levels of hepatic senescence markers are associated with liver fat and visceral adipose tissue.
From: BMP4 and Gremlin 1 regulate hepatic cell senescence during clinical progression of NAFLD/NASH
a–c, RT–qPCR analysis to assess the expression levels of SA-β-Gal (a), p21 (b) and p16 (c) in lean individuals, patients with NAFLD and patients with NASH. d,e, Amount of liver fat (%) in lean individuals, patients with NAFLD and patients with NASH (d) and its correlation with mRNA levels of hepatic senescence markers (e). f,h, Amount of visceral (f) and subcutaneous (h) fat area in lean individuals, patients with NAFLD and patients with NASH. g,i, Correlation comparisons between mRNA levels of hepatic senescence markers and visceral fat area (g) or subcutaneous fat area (i). Data were collected in lean participants (n = 12), patients with NAFLD (n = 22) and patients with NASH (n = 24). Associations were determined using Pearson or Spearman correlation analysis. Values are mean ± s.e.m. Statistical significance was determined by one-way ANOVA with post hoc Tukey’s test or Kruskal–Wallis with post hoc Dunn’s test.
